Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding

S K Chung; B G Shin; Y T Chang; B C Suh; K T Kim

doi:10.1016/s0960-894x(98)00081-x

Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding

Bioorg Med Chem Lett. 1998 Mar 17;8(6):659-62. doi: 10.1016/s0960-894x(98)00081-x.

Authors

S K Chung¹, B G Shin, Y T Chang, B C Suh, K T Kim

Affiliation

¹ Department of Chemistry, Pohang University of Science & Technology, Korea.

PMID: 9871578
DOI: 10.1016/s0960-894x(98)00081-x

Abstract

D- and L-myo-Inositol 1,2,4,5-tetrakisphosphate [D- & L-I(1,2,4,5)P4], which are analogues of D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P3], a calcium mobilizing second messenger, were synthesized via resolution of the camphanate ester of a myo-inositol derivative, and the binding affinities to I(1,4,5)P3 receptor were measured.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CHO Cells
Calcium Channels / metabolism*
Cricetinae
Inositol 1,4,5-Trisphosphate Receptors
Inositol Phosphates / chemical synthesis*
Inositol Phosphates / metabolism*
Models, Chemical
Receptors, Cytoplasmic and Nuclear / metabolism*
Stereoisomerism

Substances

Calcium Channels
Inositol 1,4,5-Trisphosphate Receptors
Inositol Phosphates
Receptors, Cytoplasmic and Nuclear
inositol-1,2,4,5-tetrakisphosphate